Drug interactions
Daridorexant + Duloxetine
Severity: Moderate
Daridorexant and Duloxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Daridorexant is a sedating orexin antagonist and duloxetine can cause somnolence and dizziness in some patients. Taken together they may add to drowsiness and impair psychomotor performance and next-day alertness, including driving ability.
What this interaction means in plain words
Daridorexant and Duloxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daridorexant belongs to Central Nervous System; Duloxetine belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Start daridorexant at the lowest effective dose and counsel the patient about next-day drowsiness and driving. Reassess the dose of either drug if daytime impairment occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Duloxetine
- Duloxetine + Isocarboxazid Contraindicated
- Duloxetine + Linezolid Contraindicated
- Duloxetine + Methylene blue Contraindicated
- Duloxetine + Phenelzine Contraindicated
- Duloxetine + Procarbazine Contraindicated
- Duloxetine + Rasagiline Contraindicated
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Duloxetine?
MediHelp rates the interaction as moderate. Daridorexant and Duloxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Daridorexant is a sedating orexin antagonist and duloxetine can cause somnolence and dizziness in some patients. Taken together they may add to drowsiness and impair psychomotor performance and next-day alertness, including driving ability.
How serious is the interaction between Daridorexant and Duloxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start daridorexant at the lowest effective dose and counsel the patient about next-day drowsiness and driving. Reassess the dose of either drug if daytime impairment occurs.
What other medicines interact with Duloxetine?
MediHelp also lists interactions of Duloxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Duloxetine page.
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