Drug interactions
Daridorexant + Pregabalin
Severity: Moderate
Daridorexant and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents cause sedation, and together they may increase next-day drowsiness and impair psychomotor performance, including driving ability.
What this interaction means in plain words
Daridorexant and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daridorexant belongs to Central Nervous System; Pregabalin belongs to Central Nervous System.
Why it happens
Additive CNS depression from orexin receptor antagonism plus pregabalin.
What to do
Monitor for daytime somnolence and impaired performance, and consider reducing the daridorexant dose. Counsel the patient about driving and alertness-requiring tasks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pregabalin
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Pregabalin?
MediHelp rates the interaction as moderate. Daridorexant and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents cause sedation, and together they may increase next-day drowsiness and impair psychomotor performance, including driving ability.
How serious is the interaction between Daridorexant and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for daytime somnolence and impaired performance, and consider reducing the daridorexant dose. Counsel the patient about driving and alertness-requiring tasks.
What other medicines interact with Pregabalin?
MediHelp also lists interactions of Pregabalin with, for example, Alprazolam, Amobarbital, Belladonna and opium. The full list is on the Pregabalin page.
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