Drug interactions
Daridorexant + Vortioxetine
Severity: Moderate
Daridorexant and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Daridorexant causes somnolence and may impair next-day psychomotor performance. Adding another CNS-active drug such as vortioxetine may add to daytime impairment, though vortioxetine is not strongly sedating.
What this interaction means in plain words
Daridorexant and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daridorexant belongs to Central Nervous System; Vortioxetine belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects via orexin receptor antagonism and serotonergic modulation.
What to do
Use the lowest effective daridorexant dose and warn patients about next-day drowsiness and driving. Reassess if daytime impairment occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Other interactions of Daridorexant
Frequently asked questions
Can I take Daridorexant with Vortioxetine?
MediHelp rates the interaction as moderate. Daridorexant and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Daridorexant causes somnolence and may impair next-day psychomotor performance. Adding another CNS-active drug such as vortioxetine may add to daytime impairment, though vortioxetine is not strongly sedating.
How serious is the interaction between Daridorexant and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective daridorexant dose and warn patients about next-day drowsiness and driving. Reassess if daytime impairment occurs.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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