Drug interactions
Darolutamide + Leflunomide
Severity: Moderate
Darolutamide and Leflunomide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darolutamide inhibits BCRP, and teriflunomide, the active metabolite of leflunomide, is a BCRP substrate. Exposure to teriflunomide may rise, increasing the risk of adverse effects such as hepatotoxicity and cytopenias.
What this interaction means in plain words
Darolutamide and Leflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darolutamide belongs to Miscellaneous; Leflunomide belongs to Musculoskeletal.
Why it happens
Darolutamide inhibition of BCRP reduces efflux of teriflunomide, raising its exposure.
What to do
Monitor liver enzymes and blood counts more closely, and consider reducing the leflunomide dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Leflunomide
- Bcg vaccine live + Leflunomide Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Leflunomide Contraindicated
- Leflunomide + Measles mumps and rubella vaccine live Contraindicated
- Leflunomide + Measles mumps rubella and varicella vaccine live Contraindicated
- Leflunomide + Measles vaccine Contraindicated
- Leflunomide + Smallpox vaccine live Contraindicated
Other interactions of Darolutamide
Frequently asked questions
Can I take Darolutamide with Leflunomide?
MediHelp rates the interaction as moderate. Darolutamide and Leflunomide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darolutamide inhibits BCRP, and teriflunomide, the active metabolite of leflunomide, is a BCRP substrate. Exposure to teriflunomide may rise, increasing the risk of adverse effects such as hepatotoxicity and cytopenias.
How serious is the interaction between Darolutamide and Leflunomide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes and blood counts more closely, and consider reducing the leflunomide dose if toxicity appears.
What other medicines interact with Leflunomide?
MediHelp also lists interactions of Leflunomide with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Leflunomide page.
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