Drug interactions
Darunavir + Estradiol
Severity: Moderate
Darunavir and Estradiol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir- or cobicistat-boosted darunavir inhibits CYP3A4 but also induces other pathways, so the net effect on estrogen is variable. Estrogen levels may change, with either excess effect or loss of efficacy.
What this interaction means in plain words
Darunavir and Estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Estradiol belongs to Endocrine.
Why it happens
CYP3A4 inhibition by darunavir with its booster, with a mixed effect from induction of other metabolic pathways.
What to do
Monitor clinical response to estradiol and adjust the dose based on symptoms and tolerability. Use a backup method if estradiol is used for contraception.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Estradiol?
MediHelp rates the interaction as moderate. Darunavir and Estradiol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir- or cobicistat-boosted darunavir inhibits CYP3A4 but also induces other pathways, so the net effect on estrogen is variable. Estrogen levels may change, with either excess effect or loss of efficacy.
How serious is the interaction between Darunavir and Estradiol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to estradiol and adjust the dose based on symptoms and tolerability. Use a backup method if estradiol is used for contraception.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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