Drug interactions
Darunavir + Finasteride
Severity: Minor
Darunavir and Finasteride: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, particularly when boosted with ritonavir or cobicistat, inhibits CYP3A4 and may raise finasteride concentrations. Finasteride tolerates increased exposure well, so serious effects are unlikely.
What this interaction means in plain words
Darunavir and Finasteride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darunavir belongs to Anti Virals; Finasteride belongs to Genitourinary.
Why it happens
Inhibition of CYP3A4-mediated finasteride metabolism.
What to do
No dose adjustment is needed; monitor for finasteride adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Finasteride
- Finasteride + Levoketoconazole Moderate
- Finasteride + Nefazodone Moderate
- Finasteride + Rifampin Moderate
- Finasteride + St john's wort Moderate
- Amobarbital + Finasteride Minor
- Aprepitant + Finasteride Minor
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Finasteride?
MediHelp rates the interaction as minor. Darunavir and Finasteride have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Darunavir, particularly when boosted with ritonavir or cobicistat, inhibits CYP3A4 and may raise finasteride concentrations. Finasteride tolerates increased exposure well, so serious effects are unlikely.
How serious is the interaction between Darunavir and Finasteride?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for finasteride adverse effects.
What other medicines interact with Finasteride?
MediHelp also lists interactions of Finasteride with, for example, Levoketoconazole, Nefazodone, Rifampin. The full list is on the Finasteride page.
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