Drug interactions
Darunavir + Glipizide
Severity: Moderate
Darunavir and Glipizide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually boosted with ritonavir or cobicistat, can cause insulin resistance and hyperglycemia and may alter glipizide exposure. This can lead to loss of glycemic control or, less commonly, hypoglycemia.
What this interaction means in plain words
Darunavir and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Glipizide belongs to Endocrine.
Why it happens
Protease inhibitor-related insulin resistance combined with variable CYP effects from the boosting agent on glipizide metabolism.
What to do
Monitor blood glucose after starting or stopping darunavir and adjust the glipizide dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Glipizide?
MediHelp rates the interaction as moderate. Darunavir and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir, usually boosted with ritonavir or cobicistat, can cause insulin resistance and hyperglycemia and may alter glipizide exposure. This can lead to loss of glycemic control or, less commonly, hypoglycemia.
How serious is the interaction between Darunavir and Glipizide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting or stopping darunavir and adjust the glipizide dose as needed.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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