Drug interactions
Darunavir + Lacosamide
Severity: Minor
Darunavir and Lacosamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A4, a minor lacosamide pathway. A significant rise in lacosamide exposure is unlikely, though it may matter in organ impairment.
What this interaction means in plain words
Darunavir and Lacosamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darunavir belongs to Anti Virals; Lacosamide belongs to Central Nervous System.
Why it happens
CYP3A4 inhibition slightly decreases lacosamide metabolism.
What to do
No empiric dose change is required. Monitor for dizziness, ataxia and PR prolongation, especially with renal or hepatic impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lacosamide
- Lacosamide + Zuranolone Major
- Atazanavir + Lacosamide Moderate
- Carbamazepine + Lacosamide Moderate
- Cenobamate + Lacosamide Moderate
- Clarithromycin + Lacosamide Moderate
- Daridorexant + Lacosamide Moderate
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Lacosamide?
MediHelp rates the interaction as minor. Darunavir and Lacosamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Darunavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A4, a minor lacosamide pathway. A significant rise in lacosamide exposure is unlikely, though it may matter in organ impairment.
How serious is the interaction between Darunavir and Lacosamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is required. Monitor for dizziness, ataxia and PR prolongation, especially with renal or hepatic impairment.
What other medicines interact with Lacosamide?
MediHelp also lists interactions of Lacosamide with, for example, Zuranolone, Atazanavir, Carbamazepine. The full list is on the Lacosamide page.
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