Drug interactions
Darunavir + Linagliptin
Severity: Minor
Darunavir and Linagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Boosted darunavir inhibits CYP3A4 and P-gp, which may raise linagliptin levels, though this is rarely significant. Antiretroviral therapy may also worsen insulin resistance and hyperglycemia.
What this interaction means in plain words
Darunavir and Linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Darunavir belongs to Anti Virals; Linagliptin belongs to Endocrine.
Why it happens
CYP3A4/P-gp inhibition by darunavir raises linagliptin exposure; protease inhibitors may also cause insulin resistance.
What to do
No linagliptin dose change needed; monitor glucose and HbA1c during antiretroviral therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin
- Alogliptin-pioglitazone + Linagliptin Moderate
- Amlodipine-benazepril + Linagliptin Moderate
- Amobarbital + Linagliptin Moderate
- Apalutamide + Linagliptin Moderate
- Benazepril + Linagliptin Moderate
- Bexarotene + Linagliptin Moderate
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Linagliptin?
MediHelp rates the interaction as minor. Darunavir and Linagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Boosted darunavir inhibits CYP3A4 and P-gp, which may raise linagliptin levels, though this is rarely significant. Antiretroviral therapy may also worsen insulin resistance and hyperglycemia.
How serious is the interaction between Darunavir and Linagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No linagliptin dose change needed; monitor glucose and HbA1c during antiretroviral therapy.
What other medicines interact with Linagliptin?
MediHelp also lists interactions of Linagliptin with, for example, Alogliptin-pioglitazone, Amlodipine-benazepril, Amobarbital. The full list is on the Linagliptin page.
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