Drug interactions
Darunavir + Methylprednisolone
Severity: Major
Darunavir and Methylprednisolone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually given with ritonavir or cobicistat, inhibits CYP3A4 and can increase methylprednisolone exposure, raising the risk of Cushing's syndrome and adrenal suppression with prolonged use. A clinically important reduction in darunavir levels is not well established.
What this interaction means in plain words
Darunavir and Methylprednisolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Darunavir belongs to Anti Virals; Methylprednisolone belongs to Endocrine.
Why it happens
Inhibition of CYP3A4-mediated methylprednisolone metabolism by the boosted darunavir regimen.
What to do
Avoid prolonged coadministration or reduce the methylprednisolone dose with close monitoring; consider an alternative corticosteroid such as prednisolone for long-term therapy.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Methylprednisolone?
MediHelp rates the interaction as major. Darunavir and Methylprednisolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Darunavir, usually given with ritonavir or cobicistat, inhibits CYP3A4 and can increase methylprednisolone exposure, raising the risk of Cushing's syndrome and adrenal suppression with prolonged use. A clinically important reduction in darunavir levels is not well established.
How serious is the interaction between Darunavir and Methylprednisolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid prolonged coadministration or reduce the methylprednisolone dose with close monitoring; consider an alternative corticosteroid such as prednisolone for long-term therapy.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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