Drug interactions
Darunavir + Mirtazapine
Severity: Moderate
Darunavir and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, especially when boosted with ritonavir or cobicistat, inhibits CYP3A4 and may raise mirtazapine concentrations. Higher exposure may cause more sedation and other dose-related adverse effects.
What this interaction means in plain words
Darunavir and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Mirtazapine belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4 mediated mirtazapine metabolism by the boosted protease inhibitor.
What to do
Titrate mirtazapine cautiously and monitor for sedation and adverse effects. Lower the dose if poorly tolerated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Mirtazapine?
MediHelp rates the interaction as moderate. Darunavir and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir, especially when boosted with ritonavir or cobicistat, inhibits CYP3A4 and may raise mirtazapine concentrations. Higher exposure may cause more sedation and other dose-related adverse effects.
How serious is the interaction between Darunavir and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate mirtazapine cautiously and monitor for sedation and adverse effects. Lower the dose if poorly tolerated.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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