Drug interactions
Darunavir + Modafinil
Severity: Moderate
Darunavir and Modafinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A4 and may raise modafinil levels. Modafinil is a weak CYP3A4 inducer and could slightly lower darunavir exposure. The overall effect is generally modest.
What this interaction means in plain words
Darunavir and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Modafinil belongs to Central Nervous System.
Why it happens
CYP3A4 inhibition by darunavir and its booster slows modafinil metabolism, while modafinil weakly induces CYP3A4.
What to do
Monitor for modafinil adverse effects and reduce the dose if needed. Monitor HIV viral load.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Modafinil
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Modafinil?
MediHelp rates the interaction as moderate. Darunavir and Modafinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A4 and may raise modafinil levels. Modafinil is a weak CYP3A4 inducer and could slightly lower darunavir exposure. The overall effect is generally modest.
How serious is the interaction between Darunavir and Modafinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for modafinil adverse effects and reduce the dose if needed. Monitor HIV viral load.
What other medicines interact with Modafinil?
MediHelp also lists interactions of Modafinil with, for example, Lenacapavir, Leniolisib, Lorlatinib. The full list is on the Modafinil page.
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