Drug interactions
Darunavir + Trimipramine
Severity: Moderate
Darunavir and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A4 and may raise trimipramine concentrations. Higher levels can increase anticholinergic effects, sedation and cardiac conduction disturbances.
What this interaction means in plain words
Darunavir and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Trimipramine belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated metabolism of trimipramine, with boosters also inhibiting CYP2D6.
What to do
Start trimipramine at a low dose and titrate to response. Monitor for toxicity and consider an ECG in patients at risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Trimipramine?
MediHelp rates the interaction as moderate. Darunavir and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir, usually boosted with ritonavir or cobicistat, inhibits CYP3A4 and may raise trimipramine concentrations. Higher levels can increase anticholinergic effects, sedation and cardiac conduction disturbances.
How serious is the interaction between Darunavir and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start trimipramine at a low dose and titrate to response. Monitor for toxicity and consider an ECG in patients at risk.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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