Drug interactions
Darunavir + Zileuton
Severity: Moderate
Darunavir and Zileuton: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually boosted with ritonavir or cobicistat, is a strong CYP3A4 inhibitor that may raise zileuton levels. Higher zileuton exposure may increase adverse effects, including hepatotoxicity.
What this interaction means in plain words
Darunavir and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Zileuton belongs to Respiratory.
Why it happens
Inhibition of CYP3A4-mediated zileuton metabolism by boosted darunavir.
What to do
Monitor liver enzymes at baseline and periodically while on the combination. Reduce or stop zileuton if ALT elevations develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zileuton
- Fezolinetant + Zileuton Contraindicated
- Pimozide + Zileuton Contraindicated
- Alosetron + Zileuton Major
- Clozapine + Zileuton Major
- Lomitapide + Zileuton Major
- Lonafarnib + Zileuton Major
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Zileuton?
MediHelp rates the interaction as moderate. Darunavir and Zileuton can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir, usually boosted with ritonavir or cobicistat, is a strong CYP3A4 inhibitor that may raise zileuton levels. Higher zileuton exposure may increase adverse effects, including hepatotoxicity.
How serious is the interaction between Darunavir and Zileuton?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes at baseline and periodically while on the combination. Reduce or stop zileuton if ALT elevations develop.
What other medicines interact with Zileuton?
MediHelp also lists interactions of Zileuton with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Zileuton page.
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