Drug interactions
Darunavir + Zonisamide
Severity: Moderate
Darunavir and Zonisamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darunavir, usually boosted with ritonavir or cobicistat, strongly inhibits CYP3A4 and may increase zonisamide exposure. Patients may experience more drowsiness, dizziness or other dose-related adverse effects.
What this interaction means in plain words
Darunavir and Zonisamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Darunavir belongs to Anti Virals; Zonisamide belongs to Central Nervous System.
Why it happens
CYP3A4 inhibition by boosted darunavir reduces zonisamide metabolism.
What to do
Monitor for zonisamide adverse effects after starting darunavir and lower the zonisamide dose if needed. Reassess when the antiretroviral regimen changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zonisamide
- Zonisamide + Zuranolone Major
- Acetazolamide + Zonisamide Moderate
- Amisulpride + Zonisamide Moderate
- Amobarbital + Zonisamide Moderate
- Apalutamide + Zonisamide Moderate
- Asenapine transdermal + Zonisamide Moderate
Other interactions of Darunavir
- Alfuzosin + Darunavir Contraindicated
- Avanafil + Darunavir Contraindicated
- Darunavir + Dronedarone Contraindicated
- Darunavir + Eletriptan Contraindicated
- Darunavir + Ergotamine Contraindicated
- Darunavir + Flibanserin Contraindicated
Frequently asked questions
Can I take Darunavir with Zonisamide?
MediHelp rates the interaction as moderate. Darunavir and Zonisamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Darunavir, usually boosted with ritonavir or cobicistat, strongly inhibits CYP3A4 and may increase zonisamide exposure. Patients may experience more drowsiness, dizziness or other dose-related adverse effects.
How serious is the interaction between Darunavir and Zonisamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for zonisamide adverse effects after starting darunavir and lower the zonisamide dose if needed. Reassess when the antiretroviral regimen changes.
What other medicines interact with Zonisamide?
MediHelp also lists interactions of Zonisamide with, for example, Zuranolone, Acetazolamide, Amisulpride. The full list is on the Zonisamide page.
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