Drug interactions
Dasatinib + Dihydroergotamine
Severity: Moderate
Dasatinib and Dihydroergotamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib is a weak CYP3A4 inhibitor and may modestly raise dihydroergotamine levels. Excess dihydroergotamine can cause vasospasm and ischemia, so even a modest increase matters.
What this interaction means in plain words
Dasatinib and Dihydroergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Dihydroergotamine belongs to Central Nervous System.
Why it happens
Dasatinib inhibits CYP3A4, which may reduce dihydroergotamine metabolism.
What to do
Prefer a non-ergot migraine therapy. If used together, monitor for numbness, coldness of the extremities and chest pain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Dihydroergotamine
- Almotriptan + Dihydroergotamine Contraindicated
- Clarithromycin + Dihydroergotamine Contraindicated
- Dihydroergotamine + Dopamine Contraindicated
- Dihydroergotamine + Dronedarone Contraindicated
- Dihydroergotamine + Efavirenz Contraindicated
- Dihydroergotamine + Eletriptan Contraindicated
Frequently asked questions
Can I take Dasatinib with Dihydroergotamine?
MediHelp rates the interaction as moderate. Dasatinib and Dihydroergotamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib is a weak CYP3A4 inhibitor and may modestly raise dihydroergotamine levels. Excess dihydroergotamine can cause vasospasm and ischemia, so even a modest increase matters.
How serious is the interaction between Dasatinib and Dihydroergotamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-ergot migraine therapy. If used together, monitor for numbness, coldness of the extremities and chest pain.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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