Drug interactions
Dasatinib + Dolasetron
Severity: Moderate
Dasatinib and Dolasetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib can prolong the QT interval, and dolasetron has a dose-related QT effect. Together they may increase arrhythmia risk, particularly with electrolyte disturbances or heart disease.
What this interaction means in plain words
Dasatinib and Dolasetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Dolasetron belongs to Gastrointestinal Tract.
Why it happens
Additive QT prolongation.
What to do
Correct hypokalemia and hypomagnesemia and obtain an ECG in at-risk patients. Consider a different antiemetic if QT risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Dolasetron?
MediHelp rates the interaction as moderate. Dasatinib and Dolasetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib can prolong the QT interval, and dolasetron has a dose-related QT effect. Together they may increase arrhythmia risk, particularly with electrolyte disturbances or heart disease.
How serious is the interaction between Dasatinib and Dolasetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct hypokalemia and hypomagnesemia and obtain an ECG in at-risk patients. Consider a different antiemetic if QT risk is high.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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