Drug interactions
Dasatinib + Erythromycin lactobionate
Severity: Major
Dasatinib and Erythromycin lactobionate: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous erythromycin inhibits CYP3A4 and can raise dasatinib exposure, increasing the risk of myelosuppression, fluid retention and pleural effusion. Both drugs also prolong the QT interval, adding arrhythmia risk.
What this interaction means in plain words
Dasatinib and Erythromycin lactobionate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Erythromycin lactobionate belongs to Anti Bacterial.
Why it happens
Erythromycin inhibits CYP3A4-mediated metabolism of dasatinib, and both agents have additive QT-prolonging effects.
What to do
Choose a non-macrolide antibiotic where possible. If unavoidable, monitor ECG, electrolytes and dasatinib toxicity, and consider reducing the dasatinib dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Dasatinib with Erythromycin lactobionate?
MediHelp rates the interaction as major. Dasatinib and Erythromycin lactobionate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Intravenous erythromycin inhibits CYP3A4 and can raise dasatinib exposure, increasing the risk of myelosuppression, fluid retention and pleural effusion. Both drugs also prolong the QT interval, adding arrhythmia risk.
How serious is the interaction between Dasatinib and Erythromycin lactobionate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Choose a non-macrolide antibiotic where possible. If unavoidable, monitor ECG, electrolytes and dasatinib toxicity, and consider reducing the dasatinib dose.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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