Drug interactions
Dasatinib + Estradiol
Severity: Minor
Dasatinib and Estradiol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib is a weak CYP3A4 inhibitor and could modestly raise estradiol levels. Clinical effect is likely small.
What this interaction means in plain words
Dasatinib and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dasatinib belongs to Oncology; Estradiol belongs to Endocrine.
Why it happens
Weak inhibition of CYP3A4 by dasatinib reduces estradiol metabolism.
What to do
No dose change is usually needed; watch for estrogenic adverse effects such as breast tenderness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Estradiol
- Anastrozole + Estradiol Contraindicated
- Estradiol + Fezolinetant Contraindicated
- Estradiol + Ospemifene Contraindicated
- Antithrombin alfa + Estradiol Major
- Antithrombin iii + Estradiol Major
- Estradiol + Exemestane Major
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Estradiol?
MediHelp rates the interaction as minor. Dasatinib and Estradiol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dasatinib is a weak CYP3A4 inhibitor and could modestly raise estradiol levels. Clinical effect is likely small.
How serious is the interaction between Dasatinib and Estradiol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed; watch for estrogenic adverse effects such as breast tenderness.
What other medicines interact with Estradiol?
MediHelp also lists interactions of Estradiol with, for example, Anastrozole, Fezolinetant, Ospemifene. The full list is on the Estradiol page.
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