Drug interactions
Dasatinib + Lenvatinib
Severity: Moderate
Dasatinib and Lenvatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so coadministration may increase arrhythmia risk. Lenvatinib labeling advises close ECG monitoring with QT-prolonging drugs.
What this interaction means in plain words
Dasatinib and Lenvatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Lenvatinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Monitor ECG and electrolytes and correct potassium, magnesium and calcium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Lenvatinib
- Amiodarone + Lenvatinib Major
- Amisulpride + Lenvatinib Major
- Asenapine + Lenvatinib Major
- Chlorpromazine + Lenvatinib Major
- Donepezil + Lenvatinib Major
- Haloperidol + Lenvatinib Major
Frequently asked questions
Can I take Dasatinib with Lenvatinib?
MediHelp rates the interaction as moderate. Dasatinib and Lenvatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so coadministration may increase arrhythmia risk. Lenvatinib labeling advises close ECG monitoring with QT-prolonging drugs.
How serious is the interaction between Dasatinib and Lenvatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes and correct potassium, magnesium and calcium abnormalities.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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