Drug interactions
Dasatinib + Levoketoconazole
Severity: Major
Dasatinib and Levoketoconazole: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole is a strong CYP3A4 inhibitor and also prolongs the QT interval, and dasatinib is a CYP3A4 substrate that prolongs QT as well. Dasatinib exposure may rise substantially, increasing the risk of toxicity and arrhythmia.
What this interaction means in plain words
Dasatinib and Levoketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Levoketoconazole belongs to Endocrine.
Why it happens
Strong CYP3A4 inhibition reduces dasatinib clearance, with additive QT prolongation.
What to do
Avoid the combination. If it cannot be avoided, reduce the dasatinib dose per labeling for strong CYP3A4 inhibitors and monitor the ECG and for dasatinib adverse effects.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Dasatinib with Levoketoconazole?
MediHelp rates the interaction as major. Dasatinib and Levoketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Levoketoconazole is a strong CYP3A4 inhibitor and also prolongs the QT interval, and dasatinib is a CYP3A4 substrate that prolongs QT as well. Dasatinib exposure may rise substantially, increasing the risk of toxicity and arrhythmia.
How serious is the interaction between Dasatinib and Levoketoconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If it cannot be avoided, reduce the dasatinib dose per labeling for strong CYP3A4 inhibitors and monitor the ECG and for dasatinib adverse effects.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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