Drug interactions
Dasatinib + Mirtazapine
Severity: Moderate
Dasatinib and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT interval prolongation, so combined use could add to arrhythmia risk, including torsades de pointes in predisposed patients. The risk is greater with electrolyte disturbance, heart disease or other QT-prolonging drugs.
What this interaction means in plain words
Dasatinib and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive QT prolongation through effects on cardiac repolarization.
What to do
Obtain a baseline ECG and monitor QTc periodically. Correct potassium and magnesium abnormalities and avoid adding other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Mirtazapine?
MediHelp rates the interaction as moderate. Dasatinib and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT interval prolongation, so combined use could add to arrhythmia risk, including torsades de pointes in predisposed patients. The risk is greater with electrolyte disturbance, heart disease or other QT-prolonging drugs.
How serious is the interaction between Dasatinib and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc periodically. Correct potassium and magnesium abnormalities and avoid adding other QT-prolonging drugs.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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