Drug interactions
Dasatinib + Sevoflurane
Severity: Moderate
Dasatinib and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib has been associated with QT prolongation and sevoflurane can lengthen repolarization as well. Together they may increase the likelihood of ventricular arrhythmia.
What this interaction means in plain words
Dasatinib and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Sevoflurane belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Review the baseline QTc and correct electrolyte abnormalities before anesthesia. Monitor the ECG perioperatively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Sevoflurane?
MediHelp rates the interaction as moderate. Dasatinib and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib has been associated with QT prolongation and sevoflurane can lengthen repolarization as well. Together they may increase the likelihood of ventricular arrhythmia.
How serious is the interaction between Dasatinib and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review the baseline QTc and correct electrolyte abnormalities before anesthesia. Monitor the ECG perioperatively.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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