Drug interactions
Dasatinib + Temsirolimus
Severity: Moderate
Dasatinib and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib may modestly increase exposure to temsirolimus and its active metabolite sirolimus through CYP3A4 inhibition. This could increase adverse effects such as myelosuppression, mucositis, hyperglycemia and pneumonitis.
What this interaction means in plain words
Dasatinib and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Temsirolimus belongs to Oncology.
Why it happens
Dasatinib inhibits CYP3A4, which metabolizes temsirolimus and sirolimus.
What to do
Monitor blood counts, glucose, lipids and respiratory symptoms for increased toxicity. Reduce the temsirolimus dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Dasatinib with Temsirolimus?
MediHelp rates the interaction as moderate. Dasatinib and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib may modestly increase exposure to temsirolimus and its active metabolite sirolimus through CYP3A4 inhibition. This could increase adverse effects such as myelosuppression, mucositis, hyperglycemia and pneumonitis.
How serious is the interaction between Dasatinib and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, glucose, lipids and respiratory symptoms for increased toxicity. Reduce the temsirolimus dose if adverse effects emerge.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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