Drug interactions
Dasatinib + Tiotropium-olodaterol
Severity: Moderate
Dasatinib and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib has been associated with QT prolongation, and olodaterol can add to arrhythmia risk via tachycardia and lower potassium. The risk is mainly relevant in patients with cardiac disease or electrolyte disturbances.
What this interaction means in plain words
Dasatinib and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Tiotropium-olodaterol belongs to Respiratory.
Why it happens
Additive effects on cardiac repolarization together with beta2-mediated sympathetic stimulation.
What to do
Correct potassium and magnesium before and during therapy and consider ECG monitoring in at-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Dasatinib and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib has been associated with QT prolongation, and olodaterol can add to arrhythmia risk via tachycardia and lower potassium. The risk is mainly relevant in patients with cardiac disease or electrolyte disturbances.
How serious is the interaction between Dasatinib and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Correct potassium and magnesium before and during therapy and consider ECG monitoring in at-risk patients.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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