Drug interactions
Dasatinib + Trazodone
Severity: Major
Dasatinib and Trazodone: major interaction.
Last updated Sources: UK SmPC
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use may increase the risk of serious arrhythmia such as torsades de pointes. Dasatinib is also a weak CYP3A4 inhibitor and may modestly increase trazodone exposure.
What this interaction means in plain words
Dasatinib and Trazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Trazodone belongs to Central Nervous System.
Why it happens
Additive QT prolongation, with weak CYP3A4 inhibition by dasatinib raising trazodone levels.
What to do
Obtain a baseline ECG and electrolytes, correct hypokalemia and hypomagnesemia, and monitor QTc periodically. Consider a lower trazodone dose or an alternative antidepressant if QTc rises significantly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
- Trazodone 50mg Capsules - SmPC sections 4.3/4.5 (class statement: drugs known to prolong the QT interval; "Concomitant use of Molipaxin/Trazodone with drugs known to prolong the QT interval may increase the risk of ventricular arrhythmias, including torsade de pointe") — electronic medicines compendium (UK SmPC)
Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Trazodone?
MediHelp rates the interaction as major. Dasatinib and Trazodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, so combined use may increase the risk of serious arrhythmia such as torsades de pointes. Dasatinib is also a weak CYP3A4 inhibitor and may modestly increase trazodone exposure.
How serious is the interaction between Dasatinib and Trazodone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and electrolytes, correct hypokalemia and hypomagnesemia, and monitor QTc periodically. Consider a lower trazodone dose or an alternative antidepressant if QTc rises significantly.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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