Drug interactions
Daunorubicin + Elagolix
Severity: Minor
Daunorubicin and Elagolix: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elagolix is a weak inhibitor of intestinal P-glycoprotein and may raise exposure to P-gp substrates such as daunorubicin. Higher anthracycline levels could increase myelosuppression and cardiotoxicity, although the effect with an intravenous drug is likely small.
What this interaction means in plain words
Daunorubicin and Elagolix have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Daunorubicin belongs to Oncology; Elagolix belongs to Musculoskeletal.
Why it happens
Elagolix inhibits P-glycoprotein efflux, potentially reducing daunorubicin clearance.
What to do
No routine adjustment is needed; monitor blood counts and cardiac function as per standard daunorubicin protocols.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Daunorubicin
- Adenovirus types 4 and 7 live + Daunorubicin Contraindicated
- Belatacept + Daunorubicin Major
- Cyclosporine + Daunorubicin Major
- Cyclosporin + Daunorubicin Major
- Daunorubicin + Dengue vaccine Major
- Daunorubicin + Etrasimod Major
Other interactions of Elagolix
- Cyclosporin + Elagolix Contraindicated
- Elagolix + Gemfibrozil Contraindicated
- Desogestrel-ethinyl estradiol + Elagolix Major
- Elagolix + Erythromycin Major
- Elagolix + Ethinyl estradiol-drospirenone Major
- Elagolix + Ethinyl estradiol-levonorgestrel Major
Frequently asked questions
Can I take Daunorubicin with Elagolix?
MediHelp rates the interaction as minor. Daunorubicin and Elagolix have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elagolix is a weak inhibitor of intestinal P-glycoprotein and may raise exposure to P-gp substrates such as daunorubicin. Higher anthracycline levels could increase myelosuppression and cardiotoxicity, although the effect with an intravenous drug is likely small.
How serious is the interaction between Daunorubicin and Elagolix?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor blood counts and cardiac function as per standard daunorubicin protocols.
What other medicines interact with Daunorubicin?
MediHelp also lists interactions of Daunorubicin with, for example, Adenovirus types 4 and 7 live, Belatacept, Cyclosporine. The full list is on the Daunorubicin page.
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