Drug interactions
Defibrotide + Fluvoxamine
Severity: Moderate
Defibrotide and Fluvoxamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Defibrotide has profibrinolytic activity and can enhance the effects of agents that affect hemostasis. Fluvoxamine impairs platelet function, so combined use may increase the risk of bleeding.
What this interaction means in plain words
Defibrotide and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Defibrotide belongs to Cardiovascular; Fluvoxamine belongs to Central Nervous System.
Why it happens
Additive effects on hemostasis from SSRI platelet dysfunction and defibrotide's profibrinolytic and antithrombotic activity.
What to do
Monitor for bleeding and consider whether fluvoxamine can be held during defibrotide therapy in patients with high bleeding risk.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Defibrotide
- Alteplase + Defibrotide Contraindicated
- Apixaban + Defibrotide Contraindicated
- Argatroban + Defibrotide Contraindicated
- Dabigatran etexilate + Defibrotide Contraindicated
- Dalteparin + Defibrotide Contraindicated
- Defibrotide + Edoxaban Contraindicated
Frequently asked questions
Can I take Defibrotide with Fluvoxamine?
MediHelp rates the interaction as moderate. Defibrotide and Fluvoxamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Defibrotide has profibrinolytic activity and can enhance the effects of agents that affect hemostasis. Fluvoxamine impairs platelet function, so combined use may increase the risk of bleeding.
How serious is the interaction between Defibrotide and Fluvoxamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and consider whether fluvoxamine can be held during defibrotide therapy in patients with high bleeding risk.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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