Drug interactions
Defibrotide + Mefenamic acid
Severity: Moderate
Defibrotide and Mefenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Defibrotide has profibrinolytic and antithrombotic activity and may increase bleeding risk when combined with drugs that impair platelet function, such as NSAIDs. Defibrotide labeling advises against concurrent use with anticoagulants or fibrinolytics.
What this interaction means in plain words
Defibrotide and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Defibrotide belongs to Cardiovascular; Mefenamic acid belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic effect on hemostasis; defibrotide enhances fibrinolysis while the NSAID inhibits platelet aggregation.
What to do
Monitor for bleeding and coagulation parameters, and avoid the NSAID where an alternative analgesic is available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Other interactions of Defibrotide
- Alteplase + Defibrotide Contraindicated
- Apixaban + Defibrotide Contraindicated
- Argatroban + Defibrotide Contraindicated
- Dabigatran etexilate + Defibrotide Contraindicated
- Dalteparin + Defibrotide Contraindicated
- Defibrotide + Edoxaban Contraindicated
Frequently asked questions
Can I take Defibrotide with Mefenamic acid?
MediHelp rates the interaction as moderate. Defibrotide and Mefenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Defibrotide has profibrinolytic and antithrombotic activity and may increase bleeding risk when combined with drugs that impair platelet function, such as NSAIDs. Defibrotide labeling advises against concurrent use with anticoagulants or fibrinolytics.
How serious is the interaction between Defibrotide and Mefenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and coagulation parameters, and avoid the NSAID where an alternative analgesic is available.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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