Drug interactions
Defibrotide + Nabumetone
Severity: Moderate
Defibrotide and Nabumetone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Defibrotide has profibrinolytic and antithrombotic properties, and NSAIDs impair platelet function, so the combination may increase bleeding risk. The effect is expected from pharmacology rather than shown in robust clinical studies.
What this interaction means in plain words
Defibrotide and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Defibrotide belongs to Cardiovascular; Nabumetone belongs to Musculoskeletal.
Why it happens
Additive effects on hemostasis from defibrotide's fibrinolytic activity and NSAID platelet inhibition.
What to do
Monitor for signs of bleeding and consider withholding nabumetone during defibrotide therapy, using a non-NSAID analgesic instead. Check platelet count and coagulation status as clinically indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Other interactions of Defibrotide
- Alteplase + Defibrotide Contraindicated
- Apixaban + Defibrotide Contraindicated
- Argatroban + Defibrotide Contraindicated
- Dabigatran etexilate + Defibrotide Contraindicated
- Dalteparin + Defibrotide Contraindicated
- Defibrotide + Edoxaban Contraindicated
Frequently asked questions
Can I take Defibrotide with Nabumetone?
MediHelp rates the interaction as moderate. Defibrotide and Nabumetone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Defibrotide has profibrinolytic and antithrombotic properties, and NSAIDs impair platelet function, so the combination may increase bleeding risk. The effect is expected from pharmacology rather than shown in robust clinical studies.
How serious is the interaction between Defibrotide and Nabumetone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding and consider withholding nabumetone during defibrotide therapy, using a non-NSAID analgesic instead. Check platelet count and coagulation status as clinically indicated.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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