Drug interactions
Defibrotide + Tranexamic acid
Severity: Moderate
Defibrotide and Tranexamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tranexamic acid is an antifibrinolytic, while defibrotide is used for hepatic veno-occlusive disease and has profibrinolytic and antithrombotic activity. Given together, they have opposing effects on fibrinolysis, so each may blunt the other. Antifibrinolytic therapy may also raise thrombotic concern in patients being treated with defibrotide.
What this interaction means in plain words
Defibrotide and Tranexamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Defibrotide belongs to Cardiovascular; Tranexamic acid belongs to Cardiovascular.
Why it happens
Pharmacodynamic antagonism: tranexamic acid inhibits plasminogen activation and fibrinolysis, whereas defibrotide enhances fibrinolytic activity.
What to do
Avoid routine concurrent use unless the bleeding risk clearly warrants it. If both are needed, monitor for bleeding and for thrombosis and reassess the need for tranexamic acid frequently.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranexamic acid
- Dienogest / estradiol valerate + Tranexamic acid Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Ethinyl estradiol-levonorgestrel + Tranexamic acid Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Ethinylestradiol + Tranexamic acid Contraindicated
- Mestranol + Tranexamic acid Contraindicated
Other interactions of Defibrotide
- Alteplase + Defibrotide Contraindicated
- Apixaban + Defibrotide Contraindicated
- Argatroban + Defibrotide Contraindicated
- Dabigatran etexilate + Defibrotide Contraindicated
- Dalteparin + Defibrotide Contraindicated
- Defibrotide + Edoxaban Contraindicated
Frequently asked questions
Can I take Defibrotide with Tranexamic acid?
MediHelp rates the interaction as moderate. Defibrotide and Tranexamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tranexamic acid is an antifibrinolytic, while defibrotide is used for hepatic veno-occlusive disease and has profibrinolytic and antithrombotic activity. Given together, they have opposing effects on fibrinolysis, so each may blunt the other. Antifibrinolytic therapy may also raise thrombotic concern in patients being treated with defibrotide.
How serious is the interaction between Defibrotide and Tranexamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine concurrent use unless the bleeding risk clearly warrants it. If both are needed, monitor for bleeding and for thrombosis and reassess the need for tranexamic acid frequently.
What other medicines interact with Tranexamic acid?
MediHelp also lists interactions of Tranexamic acid with, for example, Dienogest / estradiol valerate, Ethinyl estradiol-drospirenone, Ethinyl estradiol-levonorgestrel. The full list is on the Tranexamic acid page.
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