Drug interactions
Deflazacort + Ertugliflozin-sitagliptin
Severity: Moderate
Deflazacort and Ertugliflozin-sitagliptin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids such as deflazacort can raise blood glucose and reduce the effectiveness of ertugliflozin-sitagliptin. Hyperglycemia may require treatment adjustment during longer courses.
What this interaction means in plain words
Deflazacort and Ertugliflozin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Ertugliflozin-sitagliptin belongs to Endocrine.
Why it happens
Glucocorticoids increase insulin resistance and hepatic glucose output, opposing the glucose-lowering effect.
What to do
Monitor blood glucose during corticosteroid therapy and after dose changes or withdrawal. Intensify or reduce antidiabetic therapy accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ertugliflozin-sitagliptin
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Ertugliflozin-sitagliptin?
MediHelp rates the interaction as moderate. Deflazacort and Ertugliflozin-sitagliptin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids such as deflazacort can raise blood glucose and reduce the effectiveness of ertugliflozin-sitagliptin. Hyperglycemia may require treatment adjustment during longer courses.
How serious is the interaction between Deflazacort and Ertugliflozin-sitagliptin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during corticosteroid therapy and after dose changes or withdrawal. Intensify or reduce antidiabetic therapy accordingly.
What other medicines interact with Ertugliflozin-sitagliptin?
MediHelp also lists interactions of Ertugliflozin-sitagliptin with, for example, Albiglutide, Aripiprazole, Asenapine. The full list is on the Ertugliflozin-sitagliptin page.
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