Drug interactions
Denosumab + Hydroxychloroquine
Severity: Minor
Denosumab and Hydroxychloroquine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Denosumab carries a risk of serious infections, and hydroxychloroquine has only mild immunomodulatory activity. No clear additive effect is established for this specific pair.
What this interaction means in plain words
Denosumab and Hydroxychloroquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Denosumab belongs to Oncology; Hydroxychloroquine belongs to Musculoskeletal.
Why it happens
No established mechanism; any added infection risk would be pharmacodynamic and likely small.
What to do
No special action is required beyond routine vigilance for infection, especially if other immunosuppressants are also used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydroxychloroquine
- Arsenic trioxide + Hydroxychloroquine Contraindicated
- Cisapride + Hydroxychloroquine Contraindicated
- Dronedarone + Hydroxychloroquine Contraindicated
- Hydroxychloroquine + Pimozide Contraindicated
- Hydroxychloroquine + Thioridazine Contraindicated
- Hydroxychloroquine + Vandetanib Contraindicated
Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Frequently asked questions
Can I take Denosumab with Hydroxychloroquine?
MediHelp rates the interaction as minor. Denosumab and Hydroxychloroquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Denosumab carries a risk of serious infections, and hydroxychloroquine has only mild immunomodulatory activity. No clear additive effect is established for this specific pair.
How serious is the interaction between Denosumab and Hydroxychloroquine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No special action is required beyond routine vigilance for infection, especially if other immunosuppressants are also used.
What other medicines interact with Hydroxychloroquine?
MediHelp also lists interactions of Hydroxychloroquine with, for example, Arsenic trioxide, Cisapride, Dronedarone. The full list is on the Hydroxychloroquine page.
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