Drug interactions
Denosumab + Infliximab
Severity: Moderate
Denosumab and Infliximab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Denosumab has been linked to serious infections, particularly in patients on immunosuppressants. Combined with infliximab, which blocks TNF-alpha, the risk of serious infection may be higher.
What this interaction means in plain words
Denosumab and Infliximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Denosumab belongs to Oncology; Infliximab belongs to Musculoskeletal.
Why it happens
Additive effects on immune function from TNF blockade and RANKL inhibition.
What to do
Monitor for signs of infection. Treat serious infections promptly and consider interrupting therapy while the infection resolves.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Infliximab
- Bcg vaccine live + Infliximab Contraindicated
- Infliximab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Infliximab + Measles mumps and rubella vaccine Contraindicated
- Infliximab + Measles mumps and rubella vaccine live Contraindicated
- Infliximab + Measles mumps rubella and varicella vaccine live Contraindicated
- Infliximab + Measles vaccine Contraindicated
Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Frequently asked questions
Can I take Denosumab with Infliximab?
MediHelp rates the interaction as moderate. Denosumab and Infliximab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Denosumab has been linked to serious infections, particularly in patients on immunosuppressants. Combined with infliximab, which blocks TNF-alpha, the risk of serious infection may be higher.
How serious is the interaction between Denosumab and Infliximab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection. Treat serious infections promptly and consider interrupting therapy while the infection resolves.
What other medicines interact with Infliximab?
MediHelp also lists interactions of Infliximab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Infliximab page.
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