Drug interactions
Denosumab + Methylprednisolone
Severity: Moderate
Denosumab and Methylprednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Denosumab increases risk of serious infections, and concurrent immunosuppressive corticosteroids may add to this risk. Corticosteroid use can also be associated with hypocalcemia concerns in patients on denosumab.
What this interaction means in plain words
Denosumab and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Denosumab belongs to Oncology; Methylprednisolone belongs to Endocrine.
Why it happens
Additive immunosuppressive effects on infection risk; no pharmacokinetic interaction.
What to do
Monitor for signs of infection and ensure adequate calcium and vitamin D intake. Check serum calcium, particularly in patients with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methylprednisolone
- Bcg vaccine live + Methylprednisolone Contraindicated
- Measles mumps and rubella vaccine live + Methylprednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Methylprednisolone Contraindicated
- Measles vaccine + Methylprednisolone Contraindicated
- Methylprednisolone + Mifepristone Contraindicated
- Methylprednisolone + Rubella vaccine Contraindicated
Other interactions of Denosumab
- Abatacept + Denosumab Moderate
- Adalimumab + Denosumab Moderate
- Alefacept + Denosumab Moderate
- Alemtuzumab + Denosumab Moderate
- Anakinra + Denosumab Moderate
- Azacitidine + Denosumab Moderate
Frequently asked questions
Can I take Denosumab with Methylprednisolone?
MediHelp rates the interaction as moderate. Denosumab and Methylprednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Denosumab increases risk of serious infections, and concurrent immunosuppressive corticosteroids may add to this risk. Corticosteroid use can also be associated with hypocalcemia concerns in patients on denosumab.
How serious is the interaction between Denosumab and Methylprednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and ensure adequate calcium and vitamin D intake. Check serum calcium, particularly in patients with renal impairment.
What other medicines interact with Methylprednisolone?
MediHelp also lists interactions of Methylprednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Methylprednisolone page.
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