Drug interactions
Desflurane + Dolasetron
Severity: Moderate
Desflurane and Dolasetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dolasetron's active metabolite hydrodolasetron prolongs the QRS and QT/QTc intervals, and volatile anesthetics such as desflurane can also lengthen repolarization. Together they may increase the risk of torsades de pointes during anesthesia, particularly if electrolytes are disturbed.
What this interaction means in plain words
Desflurane and Dolasetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Dolasetron belongs to Gastrointestinal Tract.
Why it happens
Additive prolongation of cardiac repolarization (QTc) through pharmacodynamic effects on cardiac ion channels.
What to do
Consider a different antiemetic such as a non-QT-prolonging agent in patients with QT risk factors. Correct potassium and magnesium before surgery and monitor the ECG perioperatively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dolasetron
- Apomorphine + Dolasetron Contraindicated
- Dofetilide + Dolasetron Contraindicated
- Dolasetron + Ibutilide Contraindicated
- Dolasetron + Pimozide Contraindicated
- Dolasetron + Thioridazine Contraindicated
- Dolasetron + Vandetanib Contraindicated
Other interactions of Desflurane
Frequently asked questions
Can I take Desflurane with Dolasetron?
MediHelp rates the interaction as moderate. Desflurane and Dolasetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dolasetron's active metabolite hydrodolasetron prolongs the QRS and QT/QTc intervals, and volatile anesthetics such as desflurane can also lengthen repolarization. Together they may increase the risk of torsades de pointes during anesthesia, particularly if electrolytes are disturbed.
How serious is the interaction between Desflurane and Dolasetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a different antiemetic such as a non-QT-prolonging agent in patients with QT risk factors. Correct potassium and magnesium before surgery and monitor the ECG perioperatively.
What other medicines interact with Dolasetron?
MediHelp also lists interactions of Dolasetron with, for example, Apomorphine, Dofetilide, Ibutilide. The full list is on the Dolasetron page.
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