Drug interactions
Desflurane + Erythromycin lactobionate
Severity: Moderate
Desflurane and Erythromycin lactobionate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intravenous erythromycin gives high peak levels and prolongs the QT interval, and desflurane adds to repolarization delay. This raises the risk of torsades de pointes, especially with electrolyte disturbance.
What this interaction means in plain words
Desflurane and Erythromycin lactobionate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Erythromycin lactobionate belongs to Anti Bacterial.
Why it happens
Additive QT prolongation via inhibition of cardiac potassium channels.
What to do
Check QTc and correct potassium and magnesium before anesthesia. Infuse erythromycin slowly, monitor the ECG, and consider a non-macrolide alternative if QTc is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Other interactions of Erythromycin lactobionate
- Cisapride + Erythromycin lactobionate Contraindicated
- Dihydroergotamine + Erythromycin lactobionate Contraindicated
- Dronedarone + Erythromycin lactobionate Contraindicated
- Eletriptan + Erythromycin lactobionate Contraindicated
- Ergotamine + Erythromycin lactobionate Contraindicated
- Erythromycin lactobionate + Flibanserin Contraindicated
Frequently asked questions
Can I take Desflurane with Erythromycin lactobionate?
MediHelp rates the interaction as moderate. Desflurane and Erythromycin lactobionate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intravenous erythromycin gives high peak levels and prolongs the QT interval, and desflurane adds to repolarization delay. This raises the risk of torsades de pointes, especially with electrolyte disturbance.
How serious is the interaction between Desflurane and Erythromycin lactobionate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check QTc and correct potassium and magnesium before anesthesia. Infuse erythromycin slowly, monitor the ECG, and consider a non-macrolide alternative if QTc is prolonged.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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