Drug interactions
Desflurane + Fenfluramine
Severity: Minor
Desflurane and Fenfluramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenfluramine is a serotonergic agent that can raise blood pressure and, rarely, cause pulmonary hypertension and valvular disease. The interaction with desflurane is not well characterized and the concern is mainly haemodynamic instability under anesthesia.
What this interaction means in plain words
Desflurane and Fenfluramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desflurane belongs to Central Nervous System; Fenfluramine belongs to Central Nervous System.
Why it happens
No well-established mechanism; possible additive haemodynamic effects.
What to do
Monitor blood pressure and heart rhythm during anesthesia in patients taking fenfluramine. Tell the anesthesia team about the medication before surgery.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desflurane
Other interactions of Fenfluramine
- Fenfluramine + Isocarboxazid Contraindicated
- Fenfluramine + Linezolid Contraindicated
- Fenfluramine + Phenelzine Contraindicated
- Fenfluramine + Selegiline Contraindicated
- Fenfluramine + Tranylcypromine Contraindicated
- Almotriptan + Fenfluramine Major
Frequently asked questions
Can I take Desflurane with Fenfluramine?
MediHelp rates the interaction as minor. Desflurane and Fenfluramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fenfluramine is a serotonergic agent that can raise blood pressure and, rarely, cause pulmonary hypertension and valvular disease. The interaction with desflurane is not well characterized and the concern is mainly haemodynamic instability under anesthesia.
How serious is the interaction between Desflurane and Fenfluramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rhythm during anesthesia in patients taking fenfluramine. Tell the anesthesia team about the medication before surgery.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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