Drug interactions
Desflurane + Fluconazole
Severity: Moderate
Desflurane and Fluconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, so combining them during anesthesia may add to arrhythmia risk. The clinical impact is usually modest in patients without other risk factors.
What this interaction means in plain words
Desflurane and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Fluconazole belongs to Anti Fungals.
Why it happens
Additive QT prolongation.
What to do
Check the preoperative ECG and correct potassium and magnesium. Monitor the ECG intraoperatively in patients with other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluconazole
- Dihydroergotamine intranasal + Fluconazole Contraindicated
- Dihydroergotamine + Fluconazole Contraindicated
- Dofetilide + Fluconazole Contraindicated
- Domperidone + Fluconazole Contraindicated
- Dronedarone + Fluconazole Contraindicated
- Erythromycin + Fluconazole Contraindicated
Other interactions of Desflurane
Frequently asked questions
Can I take Desflurane with Fluconazole?
MediHelp rates the interaction as moderate. Desflurane and Fluconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, so combining them during anesthesia may add to arrhythmia risk. The clinical impact is usually modest in patients without other risk factors.
How serious is the interaction between Desflurane and Fluconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check the preoperative ECG and correct potassium and magnesium. Monitor the ECG intraoperatively in patients with other QT risk factors.
What other medicines interact with Fluconazole?
MediHelp also lists interactions of Fluconazole with, for example, Dihydroergotamine intranasal, Dihydroergotamine, Dofetilide. The full list is on the Fluconazole page.
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