Drug interactions
Desflurane + Lenvatinib
Severity: Moderate
Desflurane and Lenvatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, so combining them may increase the risk of torsades de pointes. This is most relevant for patients undergoing general anesthesia who also have electrolyte disturbances or underlying heart disease.
What this interaction means in plain words
Desflurane and Lenvatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Lenvatinib belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation through delayed cardiac repolarization.
What to do
Obtain a baseline ECG and correct potassium, magnesium and calcium before surgery. Monitor ECG during and after anesthesia in patients on lenvatinib.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Other interactions of Lenvatinib
- Amiodarone + Lenvatinib Major
- Amisulpride + Lenvatinib Major
- Asenapine + Lenvatinib Major
- Chlorpromazine + Lenvatinib Major
- Donepezil + Lenvatinib Major
- Haloperidol + Lenvatinib Major
Frequently asked questions
Can I take Desflurane with Lenvatinib?
MediHelp rates the interaction as moderate. Desflurane and Lenvatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, so combining them may increase the risk of torsades de pointes. This is most relevant for patients undergoing general anesthesia who also have electrolyte disturbances or underlying heart disease.
How serious is the interaction between Desflurane and Lenvatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium, magnesium and calcium before surgery. Monitor ECG during and after anesthesia in patients on lenvatinib.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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