Drug interactions
Desflurane + Lopinavir
Severity: Moderate
Desflurane and Lopinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Volatile anesthetics and ritonavir-boosted lopinavir can each lengthen the QT interval, so the combination may add to arrhythmia risk. The risk is higher with electrolyte imbalance or structural heart disease.
What this interaction means in plain words
Desflurane and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Lopinavir belongs to Anti Virals.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check baseline ECG and correct electrolytes before anesthesia. Use continuous ECG monitoring perioperatively and avoid other QT-prolonging drugs such as certain antiemetics.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Other interactions of Lopinavir
- Alfuzosin + Lopinavir Contraindicated
- Avanafil + Lopinavir Contraindicated
- Cisapride + Lopinavir Contraindicated
- Dronedarone + Lopinavir Contraindicated
- Eletriptan + Lopinavir Contraindicated
- Eplerenone + Lopinavir Contraindicated
Frequently asked questions
Can I take Desflurane with Lopinavir?
MediHelp rates the interaction as moderate. Desflurane and Lopinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Volatile anesthetics and ritonavir-boosted lopinavir can each lengthen the QT interval, so the combination may add to arrhythmia risk. The risk is higher with electrolyte imbalance or structural heart disease.
How serious is the interaction between Desflurane and Lopinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and correct electrolytes before anesthesia. Use continuous ECG monitoring perioperatively and avoid other QT-prolonging drugs such as certain antiemetics.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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