Drug interactions
Desflurane + Midodrine
Severity: Moderate
Desflurane and Midodrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Midodrine is an alpha-1 agonist that raises blood pressure and may cause reflex bradycardia, while desflurane sensitizes the myocardium to sympathomimetics and alters vascular tone. Hypertension and arrhythmias may occur, and the legacy mechanism is not well established.
What this interaction means in plain words
Desflurane and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Midodrine belongs to Miscellaneous.
Why it happens
Alpha-adrenergic vasoconstriction combined with anesthetic-related myocardial sensitization; the exact mechanism is not well established.
What to do
Monitor blood pressure and the ECG continuously during anesthesia. Consider holding the midodrine dose on the morning of surgery as guided by the anesthesiologist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Desflurane with Midodrine?
MediHelp rates the interaction as moderate. Desflurane and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Midodrine is an alpha-1 agonist that raises blood pressure and may cause reflex bradycardia, while desflurane sensitizes the myocardium to sympathomimetics and alters vascular tone. Hypertension and arrhythmias may occur, and the legacy mechanism is not well established.
How serious is the interaction between Desflurane and Midodrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and the ECG continuously during anesthesia. Consider holding the midodrine dose on the morning of surgery as guided by the anesthesiologist.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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