Drug interactions
Desflurane + Midostaurin
Severity: Moderate
Desflurane and Midostaurin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, so combined use may increase the risk of torsades de pointes. Risk is greater with electrolyte abnormalities or other QT-prolonging drugs.
What this interaction means in plain words
Desflurane and Midostaurin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Midostaurin belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check ECG and electrolytes before surgery and monitor the ECG perioperatively. Replace potassium and magnesium to normal range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Other interactions of Midostaurin
Frequently asked questions
Can I take Desflurane with Midostaurin?
MediHelp rates the interaction as moderate. Desflurane and Midostaurin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can prolong the QT interval, so combined use may increase the risk of torsades de pointes. Risk is greater with electrolyte abnormalities or other QT-prolonging drugs.
How serious is the interaction between Desflurane and Midostaurin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes before surgery and monitor the ECG perioperatively. Replace potassium and magnesium to normal range.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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