Drug interactions
Desflurane + Mirtazapine
Severity: Moderate
Desflurane and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desflurane can prolong the QT interval, and mirtazapine may contribute a small additional effect. Additive sedation and effects on blood pressure may also complicate anesthesia.
What this interaction means in plain words
Desflurane and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Mirtazapine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation and CNS depression.
What to do
Inform the anesthesia team about mirtazapine use and ensure normal electrolytes preoperatively. Monitor ECG and hemodynamics during the procedure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Other interactions of Desflurane
Frequently asked questions
Can I take Desflurane with Mirtazapine?
MediHelp rates the interaction as moderate. Desflurane and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Desflurane can prolong the QT interval, and mirtazapine may contribute a small additional effect. Additive sedation and effects on blood pressure may also complicate anesthesia.
How serious is the interaction between Desflurane and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team about mirtazapine use and ensure normal electrolytes preoperatively. Monitor ECG and hemodynamics during the procedure.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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