Drug interactions
Desflurane + Oxycodone
Severity: Moderate
Desflurane and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids lower the inhaled anesthetic concentration needed and add to respiratory depression and hypotension during and after anesthesia. Postoperative sedation and respiratory depression may be prolonged.
What this interaction means in plain words
Desflurane and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Oxycodone belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression, with an opioid-related reduction in anesthetic requirement.
What to do
The anesthetist should titrate desflurane concentration to effect and monitor ventilation and hemodynamics, including in the recovery period.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Other interactions of Desflurane
Frequently asked questions
Can I take Desflurane with Oxycodone?
MediHelp rates the interaction as moderate. Desflurane and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids lower the inhaled anesthetic concentration needed and add to respiratory depression and hypotension during and after anesthesia. Postoperative sedation and respiratory depression may be prolonged.
How serious is the interaction between Desflurane and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: The anesthetist should titrate desflurane concentration to effect and monitor ventilation and hemodynamics, including in the recovery period.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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