Drug interactions
Desflurane + Panobinostat
Severity: Major
Desflurane and Panobinostat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Panobinostat is associated with QT prolongation and arrhythmias, and volatile anesthetics can add to this effect. The combination may increase the risk of torsades de pointes.
What this interaction means in plain words
Desflurane and Panobinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Desflurane belongs to Central Nervous System; Panobinostat belongs to Oncology.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain a baseline ECG and correct potassium and magnesium before anesthesia. Monitor the ECG continuously and discuss timing of panobinostat with the oncologist for elective procedures.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Desflurane
Other interactions of Panobinostat
- Amiodarone + Panobinostat Contraindicated
- Anagrelide + Panobinostat Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chlorpromazine + Panobinostat Contraindicated
- Dronedarone + Panobinostat Contraindicated
- Haloperidol + Panobinostat Contraindicated
Frequently asked questions
Can I take Desflurane with Panobinostat?
MediHelp rates the interaction as major. Desflurane and Panobinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Panobinostat is associated with QT prolongation and arrhythmias, and volatile anesthetics can add to this effect. The combination may increase the risk of torsades de pointes.
How serious is the interaction between Desflurane and Panobinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before anesthesia. Monitor the ECG continuously and discuss timing of panobinostat with the oncologist for elective procedures.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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