Drug interactions
Desflurane + Ranolazine
Severity: Moderate
Desflurane and Ranolazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Volatile anesthetics can prolong the QT interval, adding to the effect of ranolazine. Perioperative arrhythmia risk may be increased.
What this interaction means in plain words
Desflurane and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Ranolazine belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Tell the anesthesia team about ranolazine use, monitor ECG intraoperatively, and maintain normal potassium and magnesium.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Other interactions of Desflurane
Frequently asked questions
Can I take Desflurane with Ranolazine?
MediHelp rates the interaction as moderate. Desflurane and Ranolazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Volatile anesthetics can prolong the QT interval, adding to the effect of ranolazine. Perioperative arrhythmia risk may be increased.
How serious is the interaction between Desflurane and Ranolazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Tell the anesthesia team about ranolazine use, monitor ECG intraoperatively, and maintain normal potassium and magnesium.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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