Drug interactions
Desflurane + Sotalol
Severity: Moderate
Desflurane and Sotalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Volatile anesthetics such as desflurane can prolong the QT interval and cause hypotension and bradycardia, and sotalol adds beta-blockade and QT prolongation. Perioperative arrhythmia risk may rise.
What this interaction means in plain words
Desflurane and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Sotalol belongs to Cardiovascular.
Why it happens
Additive QT prolongation and cardiovascular depression.
What to do
Inform the anesthesia team and monitor ECG and electrolytes perioperatively. Have treatment for bradycardia and torsades available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sotalol
- Arsenic trioxide + Sotalol Contraindicated
- Artemether / lumefantrine + Sotalol Contraindicated
- Disopyramide + Sotalol Contraindicated
- Dofetilide + Sotalol Contraindicated
- Dronedarone + Sotalol Contraindicated
- Droperidol + Sotalol Contraindicated
Other interactions of Desflurane
Frequently asked questions
Can I take Desflurane with Sotalol?
MediHelp rates the interaction as moderate. Desflurane and Sotalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Volatile anesthetics such as desflurane can prolong the QT interval and cause hypotension and bradycardia, and sotalol adds beta-blockade and QT prolongation. Perioperative arrhythmia risk may rise.
How serious is the interaction between Desflurane and Sotalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesia team and monitor ECG and electrolytes perioperatively. Have treatment for bradycardia and torsades available.
What other medicines interact with Sotalol?
MediHelp also lists interactions of Sotalol with, for example, Arsenic trioxide, Artemether / lumefantrine, Disopyramide. The full list is on the Sotalol page.
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