Drug interactions
Desflurane + Stiripentol
Severity: Moderate
Desflurane and Stiripentol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Stiripentol commonly causes somnolence and is used with clobazam, which adds to sedation. With desflurane, CNS depression and delayed emergence may be greater.
What this interaction means in plain words
Desflurane and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Desflurane belongs to Central Nervous System; Stiripentol belongs to Central Nervous System.
Why it happens
Additive CNS depression, with stiripentol enhancing GABAergic transmission.
What to do
Titrate desflurane to depth-of-anesthesia monitoring and continue antiseizure therapy perioperatively. Monitor respiration and recovery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Desflurane
Other interactions of Stiripentol
Frequently asked questions
Can I take Desflurane with Stiripentol?
MediHelp rates the interaction as moderate. Desflurane and Stiripentol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Stiripentol commonly causes somnolence and is used with clobazam, which adds to sedation. With desflurane, CNS depression and delayed emergence may be greater.
How serious is the interaction between Desflurane and Stiripentol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate desflurane to depth-of-anesthesia monitoring and continue antiseizure therapy perioperatively. Monitor respiration and recovery.
What other medicines interact with Desflurane?
MediHelp also lists interactions of Desflurane with, for example, Amisulpride, Anagrelide, Arsenic trioxide. The full list is on the Desflurane page.
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