Drug interactions
Desipramine + Maraviroc
Severity: Minor
Desipramine and Maraviroc: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Maraviroc has been listed as a possible CYP2D6 inhibitor, but it has not shown clinically meaningful inhibition of CYP2D6 in studies. A material rise in desipramine levels is therefore unlikely.
What this interaction means in plain words
Desipramine and Maraviroc have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Desipramine belongs to Central Nervous System; Maraviroc belongs to Anti Virals.
Why it happens
Possible weak CYP2D6 inhibition by maraviroc, not shown to be clinically significant.
What to do
No dose adjustment is needed. Monitor for tricyclic adverse effects if symptoms develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Other interactions of Maraviroc
- Amobarbital + Maraviroc Major
- Apalutamide + Maraviroc Major
- Carbamazepine + Maraviroc Major
- Clarithromycin + Maraviroc Major
- Efavirenz + Maraviroc Major
- Enzalutamide + Maraviroc Major
Frequently asked questions
Can I take Desipramine with Maraviroc?
MediHelp rates the interaction as minor. Desipramine and Maraviroc have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Maraviroc has been listed as a possible CYP2D6 inhibitor, but it has not shown clinically meaningful inhibition of CYP2D6 in studies. A material rise in desipramine levels is therefore unlikely.
How serious is the interaction between Desipramine and Maraviroc?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for tricyclic adverse effects if symptoms develop.
What other medicines interact with Desipramine?
MediHelp also lists interactions of Desipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Desipramine page.
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